Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Playroom
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sex room
Playroom meaning & definition 1 of Playroom.
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An AR game created by Sony for the PS4, which combined with Twitch streaming, exposes everyday people to internet streaming, ensuing hilarity and sleepless nights.
Playroom meaning & definition 2 of Playroom.
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a romantic pimp pad located in the heart of georgetown [visitation]s founders hall. aka the junior lounge. lost virginities are littered on the floor of this shag pad.
Playroom meaning & definition 3 of Playroom.
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