Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Punish
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The action of fucking someone real hard
Punish meaning & definition 1 of Punish.
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- To Finish or consume something.
- To fuck someone.
- To bash someone.
- To beat someone at something.
- To complete something.
Punish meaning & definition 2 of Punish.
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Someone with a personality trait so annoying theyre painful to socialize. This category may include but is not limited to:
Someone so thick that you have to explain and re-explain simple concepts to them, such as man that describes themself as a petrolhead but doesnt know the difference between a fuse and a spark plug even though his girlfriend has explained it to him twice now.
Someone who constantly ask advice on the same personal problem over and over again, then chooses to ignore you advice and do their own thing only to ask for more advice on the same issue 2 days later.
Someone who never ever stop being a [failtroll], online or offline, because they think theyre some sort of supertrolll.Punish meaning & definition 3 of Punish.
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- To defecate in a very forceful manner.
- To defecate so much in the toilet, it is effectively destroyed.
- A violent, sometimes painful expelling of fecal matter, prone to leaving splatter marks in the bowl and/or on the underside of the seat of ones toilet.
Punish meaning & definition 4 of Punish.
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To beat the shit out of someone
Punish meaning & definition 5 of Punish.
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- to have studied really hard, to hit the books
- to ace a test or exam
Punish meaning & definition 6 of Punish.
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(n) a mispronounced word, often given a different meaning than the normal pronounciation
(n) the act of mispronouncing a word in the asumption that the word means something other than its normal meaning
(v) to perform (2) or create (1) a punish; -ed, -ing
Punish meaning & definition 7 of Punish.
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To describe an unattractive girl.
Punish meaning & definition 8 of Punish.
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Verb: The act of capitalizing on/[taking advantage] of [a mistake] made by an opponent in a [competitive] activity. Mostly used in competitive sports and games.
Noun: An act describing the above.Punish meaning & definition 9 of Punish.
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Inflict a penalty or sanction on (someone) as retribution for an offense, especially a transgression of a legal or moral code.
Punish meaning & definition 10 of Punish.