Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Don jon
-
When you put lubricant in a blow up dolls mouth and you have her give you head while you watch porn
Don jon meaning & definition 1 of Don jon.
-
A guy that can get any girl even though hes an asshole he does not do the relationship type of shit.
Don jon meaning & definition 2 of Don jon.
-
When you lose your boner because youre more addicted to porn and can keep a boner while watching porn.
Don jon meaning & definition 3 of Don jon.
Similar Words