Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Ananias
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Ananias [an-uh-nahy-uhs]
-verb (used without object)to waste or kill time; evade work or responsibility by talking to, or conversing with, a significant other (often fol. by around): He ananiased around till work was over.
-verb (used with object)
to act negligently or incompetently at work, esp. due to time being spent on the phone with a significant other: You really ananiased the job.
-noun
unintentional failure to notice or consider; lack of proper attention: Owing to my ananias, the culprit got away.
Related forms:
An.a.ni.as.ing ly, adverb
Ananias meaning & definition 1 of Ananias.
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A guy whos fucks women when they are drunk.
Ananias meaning & definition 2 of Ananias.
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