Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Spiking
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This is when you engage in any adventurous activity exclusively outdoors, in most cases hiking, and you spark during the expedition.
Spiking meaning & definition 1 of Spiking.
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to lie to; to fool; to pull your leg
Spiking meaning & definition 2 of Spiking.
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The feeling you get when you REALLY have to shit, but the conditions are just not ideal.
Spiking meaning & definition 3 of Spiking.
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A particularly frustrating and violent (and usually loud) skype conversation. Usually with a grandparent or someone unused to modern technology. It doesnt start well and ends even worse.
Spiking meaning & definition 4 of Spiking.
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In theatre, it is the act of placing tape on a stage indicating to an actor where he, or she must be at an important point in the play. This occurs periodically during [blocking] and usually involves glow-in-the-dark tape.
Spiking meaning & definition 5 of Spiking.
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A male at the peak of his sexuality, I.E. verility.
Spiking meaning & definition 6 of Spiking.
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when two guys are having gay sex and one guy shoves his dick up the other guys dickhole
Spiking meaning & definition 7 of Spiking.
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A method of murder, typically by sticking a gun up the ass and firing straight up. Its pretty painful.
Spiking meaning & definition 8 of Spiking.
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present participle of spike
Spiking meaning & definition 9 of Spiking.