Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Hatchetman
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Hatchetman.
a. Nickname for Senator Orrin Hatch (R) Utah.
b. Republican point man for a divisive issue: Hatch the Hatchetman!
Hatchetman meaning & definition 1 of Hatchetman.
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symbol used by the juggalos its a man running with a meat cleaver
Hatchetman meaning & definition 2 of Hatchetman.
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The logo for [psychopathic records].Was Created and drawn by Shaggy 2 Dope of [ICP]
Hatchetman meaning & definition 3 of Hatchetman.
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