Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Brush off
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To ignore someone, sometimes completely and regard the individual as petty or insignificant
The act of standing someone up either by ignoring their phone calls, not returning their calls, or failing to meet social arrangements with the person due to being too busy for the person, lack of interest in the person, or the need to just be left alone.
Brush off meaning & definition 1 of Brush off.
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