Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Marginalize
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To opress; to blackball; to malign, smear, defame, or discredit; to lower public or private opinion--or the status--of an individual or group through hateful, deceitful, or misguided speech or action.
Marginalize meaning & definition 1 of Marginalize.
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If youre a [white man], youre doing this. If youre doing this, you are a [white man]. No exceptions.
Marginalize meaning & definition 2 of Marginalize.
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to treat someone or something as if they are not important:
Marginalize meaning & definition 3 of Marginalize.
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Treat (a person, group, or concept) as insignificant or peripheral.
Marginalize meaning & definition 4 of Marginalize.
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