Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Otitis
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Inflammation of the ear caused by the germ streptococcus pneumoniae, a.k.a. the one that causes pneumonia
Otitis meaning & definition 1 of Otitis.
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The disease which is communicable by posting several times in the Off Topic forums.May cause:Severe Diarrhea,Brain Cell Loss,Anal leakage,stool blackening,rectal crackling,and by severe diarrhea I mean SEVERE like shitting yourself constantly.
Otitis meaning & definition 2 of Otitis.
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