Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Limit
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Point at which a parabolic function becomes closest to its approaching objective.
Limit meaning & definition 1 of Limit.
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An unnatural essence of wicked-scat. Keeps it real on all levels. Shows no sign of limiting its wickedness.
Limit meaning & definition 2 of Limit.
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([name])
- [An end] [point] which cant be overridden.
- An end.
Limit meaning & definition 3 of Limit.
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Limit in Drag Racing. The fastest speed possible once the driver has taken into consideration the conditions of the car, the track and the weather.
Limit meaning & definition 4 of Limit.
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