Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Beacher
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When a turd is so big that half of it is in the water and half of it is stuck out on the dry part of the toilet....like a beached whale.
Beacher meaning & definition 1 of Beacher.
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A name referring to people going to or near the beach for vacation. A [tourist] .
Beacher meaning & definition 2 of Beacher.
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A shit the size of a whale
Beacher meaning & definition 3 of Beacher.
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