Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Distinguished
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attractive, sexy older male worth of pussy.
Distinguished meaning & definition 1 of Distinguished.
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What Paul uses instead of OLD.
Distinguished meaning & definition 2 of Distinguished.
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Very successful, authoritative, and commanding great respect.
Distinguished meaning & definition 3 of Distinguished.
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used to describe a respected and admired person, or their work:
Distinguished meaning & definition 4 of Distinguished.
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