Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Flint glass
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A soft, heavy, brilliant glass, consisting essentially of asilicate of lead and potassium. It is used for tableware, and foroptical instruments, as prisms, its density giving a high degree ofdispersive power; -- so called, because formerly the silica wasobtained from pulverized flints. Called also crystal glass. Cf.Glass.
Flint glass meaning & definition 1 of Flint glass.
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