Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Lobstering
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when u shove/force ur ass in a girls mouth while she makes her hand like a claw and squeezes ur nuts
Lobstering meaning & definition 1 of Lobstering.
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When a person becomes red in the face from taking of some kind of drug...or drinking too much...
Lobstering meaning & definition 2 of Lobstering.
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The playful and arousing act of having a companion probe and brush antennae-like objects over you while lying down on your stomach
Lobstering meaning & definition 3 of Lobstering.
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