Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Smelly
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something stinks like hell
Smelly meaning & definition 1 of Smelly.
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Your anus.
Smelly meaning & definition 2 of Smelly.
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playful affectionate way of naming a friend. Used between close friends.
Smelly meaning & definition 3 of Smelly.
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said to a beautiful girlfriend as a term of affection
Smelly meaning & definition 4 of Smelly.
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Not pleasing to the nostrils.
Unbearable stenchSmelly meaning & definition 5 of Smelly.
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a gathering of 20 or more hippies
Smelly meaning & definition 6 of Smelly.
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A type of smell bad or good. Often used to announce you smell like shit.
Smelly meaning & definition 7 of Smelly.
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- A pungent smell that is offensive to the nostrals.
- A very good dubstep beat
- Can be also used to describe a night (or day) that featured more debauchery that usual.
Smelly meaning & definition 8 of Smelly.
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Having a strong or unpleasant smell.
Smelly meaning & definition 9 of Smelly.
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[Weed] ([Skunk] Weed)
Smelly meaning & definition 10 of Smelly.
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