Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Stairway
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short for stairway to heaven
the last thing you wanna hear from an amateur when you go into a music instrument shop.
Stairway meaning & definition 1 of Stairway.
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the song that EVERYBODY (n00bs especially)freaking plays when in a guitarcenter etc. trying out a guitar.
Stairway meaning & definition 2 of Stairway.
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A set of steps or stairs and its surrounding walls or structure.
Stairway meaning & definition 3 of Stairway.
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The stairway is the booty, as in the stairway to heave vs the mountains of madness.(boobs)
Stairway meaning & definition 4 of Stairway.
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a passage in a public place with a set of steps that leads from one level to another
Stairway meaning & definition 5 of Stairway.
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