Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Puckered
-
Scared (enough that your butt cheeks tense up and your asshole puckers).
Puckered meaning & definition 1 of Puckered.
-
being a bitch, loser, fag or anything negative.
Puckered meaning & definition 2 of Puckered.
-
When a man is getting a blow-job, and he ejaculates in the womans mouth, she stands up and kisses him while spitting his cum back into his mouth.
Puckered meaning & definition 3 of Puckered.
-
past simple and past participle of pucker
Puckered meaning & definition 4 of Puckered.
Similar Words