Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Kelter
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Regular order or proper condition. [Written also kilter.][Colloq.]If the organs of prayer be out of kelter or out of tune, how can wepray Barrow.
Kelter meaning & definition 1 of Kelter.
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*to take a dump in your pants, on something, or somewhere.
*a synonym for shit in the new milford, ct area
Kelter meaning & definition 2 of Kelter.
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