Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Undercoat
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A coat worn under another; a light coat, as
distinguished from an overcoat, or a greatcoat.
Undercoat meaning & definition 1 of Undercoat.
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A layer of paint applied after the primer and before the topcoat.
Undercoat meaning & definition 2 of Undercoat.
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a first layer of paint that is put on a surface in order to improve the appearance of the final one, or the paint used for this:
Undercoat meaning & definition 3 of Undercoat.
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