Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Dignitary
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One who possesses exalted rank or holds a position of dignityor honor; especially, one who holds an ecclesiastical rank above thatof a parochial priest or clergyman.
Dignitary meaning & definition 1 of Dignitary.
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(noun) A telephone found next to the toilet in hotel bathrooms.
Dignitary meaning & definition 2 of Dignitary.
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a person who has an important position in a society:
Dignitary meaning & definition 3 of Dignitary.
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