Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Overly
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Careless; negligent; inattentive; superfical; not thorough.
Overly meaning & definition 1 of Overly.
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To Exceed; Avoid Limitations; To Be Extremely or Abundantly over the top. To be annoyingly exclamatory. Very Obnoxious, or, in some circumstances, said to reject the truth being presented before ones self.
Derives from Swiss German Uberlicht.Overly meaning & definition 2 of Overly.
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it is when a person is doin sumthin dumb that they shouldnt be doin.
Overly meaning & definition 3 of Overly.
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In excess of the norm
Overly meaning & definition 4 of Overly.
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A sad, sad sham of a word intended as to an excessive degree. Ironically, rather than simplifying things for those with short attention spans, the use of overly adds syllables not to be found where the prefix over- (as in overly confident/overconfident) or the adverb too (as in overly tired/too tired) are employed. Seriously, are these people incapable of too? What about excessively if you want to sound smart? Overly retarded, thats what it is.
Overly meaning & definition 5 of Overly.
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Overly meaning & definition 6 of Overly.