Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Opposable
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Capable of being placed opposite something else; as, the
thumb is opposable to the forefinger.
Opposable meaning & definition 1 of Opposable.
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(of the thumb of a primate) capable of facing and touching the other digits on the same hand.
Opposable meaning & definition 2 of Opposable.
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A term used [in the game] [Cards Against Humanity] to make everyone think it says [opposite].
Opposable meaning & definition 3 of Opposable.
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Opposable thumbs are thumbs that can be put opposite the fingers of the same hand, so that objects can be picked up and held:
Opposable meaning & definition 4 of Opposable.
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