Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Lash
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,. v. i. To ply the whip; to strike; to uttercensure orsarcastic language.To laugh at follies, or to lash at vice. Dryden.To lash out, to strike out wildly or furiously.
Lash meaning & definition 1 of Lash.
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a night on the town heavily drinking with your friends, pub crawling.
Lash meaning & definition 2 of Lash.
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Heavy Drinking, usually at night time and purpotrated by a group of lads, although females occasionally can join.
Lash meaning & definition 3 of Lash.
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to go out have a good time drink loads, smoking loads, and bantering and pulling loads of people
Lash meaning & definition 4 of Lash.
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When you let someone borrow something, because they have fuck to do.
Lash meaning & definition 5 of Lash.
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When you are having sex.
Lash meaning & definition 6 of Lash.
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to take without permission or take drugs
Lash meaning & definition 7 of Lash.
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a really hott guy/girl.
Lash meaning & definition 8 of Lash.
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when someone makes you angry or annoys you,you react to it
the reaction is lashing
Lash meaning & definition 9 of Lash.
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To rudely leave a person or people without an explantion or apology.
Lash meaning & definition 10 of Lash.
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pure jay as it is the term to describe ultimate coolness!!!
Lash meaning & definition 11 of Lash.
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Strike or beat with a whip or stick.
Lash meaning & definition 12 of Lash.