Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Enameled
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Coated or adorned with enamel; having a glossy or variegatedsurface; glazed. [Written also enamelled.]
Enameled meaning & definition 1 of Enameled.
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adj. The state of being completely and totally intoxicated to the point where reality becomes an illusion.
Enameled meaning & definition 2 of Enameled.
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a decorative glass-like substance that is melted onto clay, metal, or glass objects, and then left to cool and become hard, or an object covered with this substance
Enameled meaning & definition 3 of Enameled.
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