Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Damn it
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A phrase used on the show 24. Most often used by Jack Bauer to express extreme anger or frustration.
Damn it meaning & definition 1 of Damn it.
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to say it when you stuff things up
Damn it meaning & definition 2 of Damn it.
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Another example of how idiots spell dammit. You only say damn it if you are saying something like, Damn it all to hell.
Damn it meaning & definition 3 of Damn it.
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an expression of anger:
Damn it meaning & definition 4 of Damn it.
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