Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Keep it up
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If said in a cheerful, praising tone, it means Youre doing great, continue the good work!
If said in a warning tone, it is a threat that means Stop it right now, or reap the consequences!
Keep it up meaning & definition 1 of Keep it up.
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Sarcastic phrase used when one really wants to say something like shove off, fuck off, eat shit, kick rocks, go to hell or simply stop.
Keep it up meaning & definition 2 of Keep it up.
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It means to keep your dick hard during sex.
Keep it up meaning & definition 3 of Keep it up.
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