Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Commitment
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Commitment is what
Transforms the promise into reality.
It is the words that speak
Boldly of your intentions.
And the actions which speak
Louder than the words.
It is making the time
When there is none.
Coming through time
After time after time,
Year after year after year.
Commitment is the stuff
Character is made of;
The power to change
The face of things.
It is the daily triumph
Of integrity over skepticism.
Commitment meaning & definition 1 of Commitment.
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Something men are frequently afraid of.
Proposal of this will most definently end a relationship.Commitment meaning & definition 2 of Commitment.
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sticking with something long after the mood you have said it in has left you..
Commitment meaning & definition 3 of Commitment.
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The Black Knight. Nuff Said.
Commitment meaning & definition 4 of Commitment.
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To be loyal to an organization, person or fan base
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The act of committing
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The act of following through
Commitment meaning & definition 5 of Commitment.
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What crazy women try to trap unsuspecting men into. Women often use manipulating words and their sweet vag to get it. Having children is also an option. Bring your own condoms, get in, get off, and get out to avoid.
Commitment meaning & definition 6 of Commitment.
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The act of committing, or putting in charge, keeping,
or trust; consignment; esp., the act of committing to prison.Commitment meaning & definition 7 of Commitment.
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The state or quality of being dedicated to a cause, activity, etc.
Commitment meaning & definition 8 of Commitment.
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a promise or firm decision to do something:
Commitment meaning & definition 9 of Commitment.