Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
O-face
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The face made while banging the chick from logistics.
O-face meaning & definition 1 of O-face.
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Face made when one reaches the peak of sexual orgasm.
O-face meaning & definition 2 of O-face.
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The expression that the letter O from sesame street makes when ejaculating
O-face meaning & definition 3 of O-face.
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O-Face, also known as Outro Face, is attractive in many cultures, but not yours. It is generally used when you crave to see an outro to a point where if you dont, your kidneys will turn inside out, your eyes will be sucked into a vortex and your brain will explode.
O-face meaning & definition 4 of O-face.
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Orgasm face, the face you make when you are peaking sexual pleasure and cumming
O-face meaning & definition 5 of O-face.
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