Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Forearms
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A symbol of total [badassedness]. Usually developed from hundreds of sessions of [jacking off], and pulling back pipe on a [drilling rig]. Having [massive] forearms apparently makes it impossible to be beaten in [arm wrestling].
Forearms meaning & definition 1 of Forearms.
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fantasy football forum.
Forearms meaning & definition 2 of Forearms.
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