Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Toggles
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The Toggles are basically dwarf-like creatures that sneak into your room at night and steal objects, misplacing them, sometimes permanently. The Toggles have an affinity for finding your marijuana and making it disappear. Additionally, they love the smell of copper and will often times only try to steal and misplace your pennies, usually in really strange places.
they are closely related to pick gnomes, who are relentless in stealing guitar picks.
Toggles meaning & definition 1 of Toggles.
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a small bar of wood or plastic that is used to fasten something by being put through a hole or loop
Toggles meaning & definition 2 of Toggles.
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