Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Freezer
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One who, or that which, cools or freezes, as a refrigerator, orthe tub and can used in the process of freezing ice cream.
Freezer meaning & definition 1 of Freezer.
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a prude, someone who freezes all the action or won't put out, someone who abnormally reluctant to engage in sexual activity
Freezer meaning & definition 2 of Freezer.
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The place where you keep your ICE ([diamonds]) like the [drawer] where rappers keep their [jewelry]
Freezer meaning & definition 3 of Freezer.
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[Winter] in a [box]
Freezer meaning & definition 4 of Freezer.
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to [get raped] into [a gang] [bang in] a freezer
Freezer meaning & definition 5 of Freezer.
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- The best place to put things you dont want to look at.
- [A good place] for safe-keeping. [Fire] [safe].
Freezer meaning & definition 6 of Freezer.
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Poker term used to describe when two or more coolers are dealt in the same hand. An example of a freezer would be if one player was dealt AA, another KK, and a third QQ.
More commonly seen with [online poker] rooms such [FullTilt], [Pokerstars], or Cake.Freezer meaning & definition 7 of Freezer.
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A girl who has [sex] with [a lot] of [men].
Freezer meaning & definition 8 of Freezer.
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[One day], a girl meant to call some one [a freak] and a loser, but they just combined them into freezer. The name [stuck] and now is used by other people.
Freezer meaning & definition 9 of Freezer.
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A refrigerated cabinet or room for preserving food at very low temperatures.
Freezer meaning & definition 10 of Freezer.
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a container, operated by electricity, that stores food at a very cold temperature so that it becomes solid and can be kept safely for a long time:
Freezer meaning & definition 11 of Freezer.