Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Apple pie
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A pie made of apples (usually sliced or stewed) with spice andsugar. Apple-pie bed, a bed in which, as a joke, the sheets are sodoubled (like the cover of an apple turnover) as to prevent any onefrom getting at his length between them. Halliwell, Conybeare.-- Apple-pie order, perfect order or arrangement. [Colloq.]Halliwell.
Apple pie meaning & definition 1 of Apple pie.
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a sweet food made from apples cooked under or inside pastry:
Apple pie meaning & definition 2 of Apple pie.
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