Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Collared
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Wearing a collar; -- said of a man or beast used as a bearingwhen a collar is represented as worn around the neck or loins.
Collared meaning & definition 1 of Collared.
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[Detained], To keep from proceeding.
Collared meaning & definition 2 of Collared.
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(of a garment) having a collar.
Collared meaning & definition 3 of Collared.
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A term used to define [relationship status] after one party has received a [necklace] (or in some cases, a [bracelet]) from their significant other; a sign of romantic possession.
Collared meaning & definition 4 of Collared.
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past simple and past participle of collar
Collared meaning & definition 5 of Collared.
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