Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Crankle
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To break into bends, turns, or angles; to crinkle.Old Veg's stream . . . drew her humid train aslope, Crankling herbanks. J. Philips.
Crankle meaning & definition 1 of Crankle.
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Crease left in your ankle by socks or tapered pants. Not to be confused with Cankles
Crankle meaning & definition 2 of Crankle.
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A person that gets inured easily, and constantly hurts themselves.
Crankle meaning & definition 3 of Crankle.
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The bump/bone on ur ankle
Crankle meaning & definition 4 of Crankle.
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A crack or pop of the ankle.
Crankle meaning & definition 5 of Crankle.
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