Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Cheerful
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Having or showing good spirits or joy; cheering; cheery;contented; happy; joyful; lively; animated; willing.To entertain a cheerful disposition. Shak.The cheerful birds of sundry kind Do chant sweet music. Spenser.A cheerful confidence in the mercy of God. Macaulay.This general applause and cheerful shout. Shak.
Cheerful meaning & definition 1 of Cheerful.
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An adjective describing someone so happy that they have a smile on their face. A lot.
Cheerful meaning & definition 2 of Cheerful.
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Happy
Cheerful meaning & definition 3 of Cheerful.
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SprinkleofGlitter, is the happiest most fun loving person you could ever met.
Cheerful meaning & definition 4 of Cheerful.
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happy and positive:
Cheerful meaning & definition 5 of Cheerful.
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Noticeably happy and optimistic.
Cheerful meaning & definition 6 of Cheerful.
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