Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Däch
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By far the most offensive word ever. With origins in the Kurmanji dialect of the Kurdish language, däch is now a world-wide phenomenon, widely used all over the world. It is disputed whether däch can be used an interjection (like [fuck]), or simply as the more common derogatory term for a person (like [bastard]). It’s offensiveness, however, is never disputed, and däch is not to be misused.
Däch meaning & definition 1 of Däch.
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