Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Comstock
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reformer, reformist, crusader, meliorist
Comstock meaning & definition 1 of Comstock.
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one who associates with anothers dog
Comstock meaning & definition 2 of Comstock.
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A word to describe a glutton, one who begs for food until he/she becomes so frustrated that he/she bites you on the leg. Typically a fat yet very attractive individual, slothful yet endearing. Sometimes has eye herpes and a missing front tooth.
Comstock meaning & definition 3 of Comstock.
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