Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Cub
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A term used in gay circles to describe a young, husky, hairy gay man. Essentially a young bear.
Cub meaning & definition 1 of Cub.
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A [cougars] much younger lover. The boy is often called her cub. Cubs are usually sexy young guys that cougars keep around for company whether it be sex or to make her feel young again...cubs are often in relationships with their cougars. Always together. Hes more than a [boy toy] to his [cougar] hes her [cub].
Cub meaning & definition 2 of Cub.
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tr.v. cubbed, cubb·ing, cubs To cause to feel self-conscious or ill at ease; disconcert
Cub meaning & definition 3 of Cub.
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A younger male that is not quite bear size. For gay men, the term cub is used to describe a younger (or younger-looking) male that is usually husky or heavier in body type and is almost always hairy.
Cub meaning & definition 4 of Cub.
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The young of a fox, bear, lion, or other carnivorous mammal.
Cub meaning & definition 5 of Cub.