Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Biff
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To screw up, wipe out, or otherwise make a mistake.
Biff meaning & definition 1 of Biff.
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Adjective used to describe someone who requires little intelligence for their job.
Biff meaning & definition 2 of Biff.
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To Fall HARD
Biff meaning & definition 3 of Biff.
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a northen term for cigarette, but can also be used to discribe a joint
Biff meaning & definition 4 of Biff.
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v. To mess something up, specifically a physical activity.
Biff meaning & definition 5 of Biff.
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An online genderless Twitter personality famous for their off-the-wall banter and good will.
Biff meaning & definition 6 of Biff.
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To strike or blow.
Biff meaning & definition 7 of Biff.
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Just another word for a nasty rip-roaring good old fashioned fart.
Biff meaning & definition 8 of Biff.
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a womans naughty area aka pussy, fanny and so on
Biff meaning & definition 9 of Biff.
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Strike (someone) roughly or sharply with the fist.
Biff meaning & definition 10 of Biff.
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to hit someone, especially with the fist (= closed hand) :
Biff meaning & definition 11 of Biff.
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