Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Gaffle
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to steal
Gaffle meaning & definition 1 of Gaffle.
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To rip someone off,To get someones money by deceit.To scam someone for thier money by creating a ploy.To get over on a person or persons.
Its an old slang term used in the early part of the 20th century.Depicted in the movie The Sting.
It was picked up again in the Bay Area in the 1980s(mainly Oakland I believe)Gaffle meaning & definition 2 of Gaffle.
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v. - to steal
Gaffle meaning & definition 3 of Gaffle.
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To get arrested by the police.
Gaffle meaning & definition 4 of Gaffle.
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to detained, tie up, usually with ill intentions
Gaffle meaning & definition 5 of Gaffle.
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n. fake illicit drug
Gaffle meaning & definition 6 of Gaffle.
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Gaffle meaning & definition 7 of Gaffle.
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to [jump] upon someone causing them [pain] usually in a large group all [gaffling] one person
Gaffle meaning & definition 8 of Gaffle.
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