Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Fabricate
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To make something up. To create. To lie. To produce.
Fabricate meaning & definition 1 of Fabricate.
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(1)To over emphasize a story that ultimately has no plot or real conclusion (2) to draw conclusions in the least linear fashion possible (3) to make connections using evidence that has little to no relevance and arrives to a conclusion that was never brought up in the first place
Fabricate meaning & definition 2 of Fabricate.
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Invent (something) in order to deceive.
Fabricate meaning & definition 3 of Fabricate.
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