Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Way back
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A close friend you have known for a long time, a homey from back in the day
Way back meaning & definition 1 of Way back.
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The rear facing seat in the very back (third row) of a 1960s era Station Wagon. It folded down into the floor for a smooth cargo area or folded up as a smaller bench seat, often the youngest kids were seated there. Very dangerous location if there was a collision, especially as there were often no seat belts.
Maybe the reason for the title of the movie The Way Way Back is because Duncan couldnt get far enough away from Steve Carell even in the Way Back.Way back meaning & definition 2 of Way back.
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