Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Ferreting
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Ferreting is derived from the use of ferrets in hunting With their long, lean build, and inquisitive nature, ferrets are very well equipped for getting down holes. The term has evolved into a sexual context where two or more males “ferret” an unsuspecting “rabbit burrow” (female) often referred to as “the rabbit”. In the context of hunting one puts a ferret into each hole and leaving one hole available to observe and capture the discharge. To truly perform the act of ferreting one must not have washed for a good few days the participant’s skin must be rife with all the sweat, grit and revolting bodily odours that make a man a man.
Ferreting meaning & definition 1 of Ferreting.
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1.) Cuddling that is incredibly comfortable although may appear odd to outside viewers
2.) To cuddle, only in a fashion that resembles how ferrets lay and sleep: bundled over one another. A very comfortable way to cuddle with a significant otherFerreting meaning & definition 2 of Ferreting.
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Manovering round a night club or similar establishment, placing stickers of your face on girls breats.
A popular challenge for a [stag] on his last night of Freedom.
Technique: [Pat Pat Grope]
Ferreting meaning & definition 3 of Ferreting.
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The act of scratching ones own a**hole.
Ferreting meaning & definition 4 of Ferreting.
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A game gay males play buy letting ferrets run up their ass.
Ferreting meaning & definition 5 of Ferreting.
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present participle of ferret
Ferreting meaning & definition 6 of Ferreting.