Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Coiner
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A whiny prepish person whom gripes and complains about not getting banker hours at work. One typically finds these individuals slothing about, attempting to grab the spotlight whenever possible
Coiner meaning & definition 1 of Coiner.
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In a free-to-play videogame, a Coiner is someone who pays real money in order to get an advantage over free players. The term possibly originated in Exteel, where the real money equivalent was termed NCcoin.
The term is seldom used to describe people who pay for things which dont give a gameplay advantage over free players, such as cosmetic modifications.Coiner meaning & definition 2 of Coiner.
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A person who creates coinage, as in making the physical currency;
A person who coins or mints new words that catch on and enjoy general usage. NOTE: Just as with money (the origin of the metaphor) there are legitimate coiners whose product has value...and there are counterfeiters who produce cheap, fake, debased words that devalue the language.
Coiner meaning & definition 3 of Coiner.