Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Stepchildren
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Children of your new wife; complete drains on your patience and bank account. Good at practicing mind control, especially when they want something from you (money, car repairs, etc). AKA The bitches from hell.
Stepchildren meaning & definition 1 of Stepchildren.
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notably referred to as the balls.
Stepchildren meaning & definition 2 of Stepchildren.
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