Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Epidemic
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(dictionary) Widespread contagion, usually a bacteria or virus, that kills or severly sickens a large number people in a particular geographic area.
(American Media) Half-assed drug or dumbass activity that kills a couple suburban white kids, usually in the Baltimore area for some reason.
Epidemic meaning & definition 1 of Epidemic.
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Awesome general positive adjective.
Epidemic meaning & definition 2 of Epidemic.
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Something that is cooler than cool...
Epidemic meaning & definition 3 of Epidemic.
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A disease that has started killing white people. Until then, its just a disease, regardless of how many have already died.
Epidemic meaning & definition 4 of Epidemic.
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A widespread occurrence of an infectious disease in a community at a particular time.
Epidemic meaning & definition 5 of Epidemic.
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