Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Underarm
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The soft pocket of skin beneath the shoulder that joins the inner part of the arm to the body.
Underarm meaning & definition 1 of Underarm.
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The wrong way to bowl in a Cricket match. This happened most memorably in a Australia vs New Zealand match in 1981 where the dirty Australians were very unsporting and stole the series by bowling the ball underarm instead of overarm, preventing the New Zealand batsman to score the 6 runs needed to win the series. Goes directly against the Gentlemanly nature of the game.
Underarm meaning & definition 2 of Underarm.
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A pussys way of saying armpit.
Underarm meaning & definition 3 of Underarm.
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A person
Underarm meaning & definition 4 of Underarm.
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of or for use in the armpit (= hollow place under the arm where the arm joins the body) :
Underarm meaning & definition 5 of Underarm.
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