Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Knave
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An unprincipled, crafty fellow.
Knave meaning & definition 1 of Knave.
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n : a tricky man
Knave meaning & definition 2 of Knave.
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A manservant
A [n00b]Knave meaning & definition 3 of Knave.
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1: a pimp..
2: a god..
3. a nobody..Knave meaning & definition 4 of Knave.
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a random name to call someone who acts like a n00b
Knave meaning & definition 5 of Knave.
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To be used only in conjunction with Fucking.
Knave meaning & definition 6 of Knave.
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The name of someone who fucks their female cousins dog.
Knave meaning & definition 7 of Knave.
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jeetest pker evar
terror of the wild
star of many an erotic productionKnave meaning & definition 8 of Knave.
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A dishonest or unscrupulous man.
Knave meaning & definition 9 of Knave.
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