Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Downloaded
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the past tense of download or downloading, download is used when a download is complete. It also must be underlined and followed by a period.
Downloaded meaning & definition 1 of Downloaded.
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Slang;
Another way of saying ooo Burn! Or Youve just been burned!
Said when someone was well insulted or humiliated.Downloaded meaning & definition 2 of Downloaded.
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