Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Stube
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Meaning stupid cubed. If you are trying to explain someone or something that is really stupid and saying stupid just doesnt justify it, try using stube.
Stube meaning & definition 1 of Stube.
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Noun or verb. One who passively trolls to recieve annonymous anal sex, primarily a male homosexual term. To engage in such behavior. (syn.n~stuber, syn.v~stubing)
Stube meaning & definition 2 of Stube.
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German slang for a small and uncomfortable room, having the meaning of a barrel.
Stube meaning & definition 3 of Stube.
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